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inactive mek1  (Carna Inc)


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    Structured Review

    Carna Inc inactive mek1
    Kinase binding experiments and molecular docking of nemtabrutinib. Sensorgrams of nemtabrutinib and reference inhibitor binding in surface plasmon resonance experiments with <t>MEK1</t> (a) or B-RAF (b) . The red and grey lines represent the experimental results and the black lines represent the fits obtained using a 1:1 binding model. (c) Binding mode of nemtabrutinib in the ATP-binding pocket of BTK (PDB ID: 6E4F). (d) Highest-scoring docking pose of nemtabrutinib in the ATP-binding pocket of MEK1 (PDB ID: 7XLP).
    Inactive Mek1, supplied by Carna Inc, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/map2k1%5Binactive%5D/pmc12586182-54-6-8?v=Carna+Inc
    Average 94 stars, based on 2 article reviews
    inactive mek1 - by Bioz Stars, 2026-07
    94/100 stars

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    1) Product Images from "Combined cellular and biochemical profiling of Bruton’s tyrosine kinase inhibitor nemtabrutinib reveals potential application in MAPK-driven cancers"

    Article Title: Combined cellular and biochemical profiling of Bruton’s tyrosine kinase inhibitor nemtabrutinib reveals potential application in MAPK-driven cancers

    Journal: Frontiers in Oncology

    doi: 10.3389/fonc.2025.1667291

    Kinase binding experiments and molecular docking of nemtabrutinib. Sensorgrams of nemtabrutinib and reference inhibitor binding in surface plasmon resonance experiments with MEK1 (a) or B-RAF (b) . The red and grey lines represent the experimental results and the black lines represent the fits obtained using a 1:1 binding model. (c) Binding mode of nemtabrutinib in the ATP-binding pocket of BTK (PDB ID: 6E4F). (d) Highest-scoring docking pose of nemtabrutinib in the ATP-binding pocket of MEK1 (PDB ID: 7XLP).
    Figure Legend Snippet: Kinase binding experiments and molecular docking of nemtabrutinib. Sensorgrams of nemtabrutinib and reference inhibitor binding in surface plasmon resonance experiments with MEK1 (a) or B-RAF (b) . The red and grey lines represent the experimental results and the black lines represent the fits obtained using a 1:1 binding model. (c) Binding mode of nemtabrutinib in the ATP-binding pocket of BTK (PDB ID: 6E4F). (d) Highest-scoring docking pose of nemtabrutinib in the ATP-binding pocket of MEK1 (PDB ID: 7XLP).

    Techniques Used: Binding Assay, SPR Assay



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    Kinase binding experiments and molecular docking of nemtabrutinib. Sensorgrams of nemtabrutinib and reference inhibitor binding in surface plasmon resonance experiments with <t>MEK1</t> (a) or B-RAF (b) . The red and grey lines represent the experimental results and the black lines represent the fits obtained using a 1:1 binding model. (c) Binding mode of nemtabrutinib in the ATP-binding pocket of BTK (PDB ID: 6E4F). (d) Highest-scoring docking pose of nemtabrutinib in the ATP-binding pocket of MEK1 (PDB ID: 7XLP).
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    Image Search Results


    Kinase binding experiments and molecular docking of nemtabrutinib. Sensorgrams of nemtabrutinib and reference inhibitor binding in surface plasmon resonance experiments with MEK1 (a) or B-RAF (b) . The red and grey lines represent the experimental results and the black lines represent the fits obtained using a 1:1 binding model. (c) Binding mode of nemtabrutinib in the ATP-binding pocket of BTK (PDB ID: 6E4F). (d) Highest-scoring docking pose of nemtabrutinib in the ATP-binding pocket of MEK1 (PDB ID: 7XLP).

    Journal: Frontiers in Oncology

    Article Title: Combined cellular and biochemical profiling of Bruton’s tyrosine kinase inhibitor nemtabrutinib reveals potential application in MAPK-driven cancers

    doi: 10.3389/fonc.2025.1667291

    Figure Lengend Snippet: Kinase binding experiments and molecular docking of nemtabrutinib. Sensorgrams of nemtabrutinib and reference inhibitor binding in surface plasmon resonance experiments with MEK1 (a) or B-RAF (b) . The red and grey lines represent the experimental results and the black lines represent the fits obtained using a 1:1 binding model. (c) Binding mode of nemtabrutinib in the ATP-binding pocket of BTK (PDB ID: 6E4F). (d) Highest-scoring docking pose of nemtabrutinib in the ATP-binding pocket of MEK1 (PDB ID: 7XLP).

    Article Snippet: The binding of nemtabrutinib to biotinylated, inactive MEK1 (Carna Biosciences, Inc., cat. no. 07-441-10-20N) and activated B-RAF (Carna Biosciences, Inc., cat. no. 09-422-20N) was measured by surface plasmon resonance (SPR) using a Biacore 1S+ (Cytiva), as described previously ( ).

    Techniques: Binding Assay, SPR Assay